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Wednesday, May 27, 2009
MERCURY: Influences on Body Chemistry
Mercury and Mental Health
Bioplar Disorder: A possible dental connection
By Dr. Gerald H. Smith
I was inspired to write this article after watching Jane Pauley's appearance and promotion of her new book, Skywriting: A Life Out of the Blue, on the September 3rd , 2004 David Letterman show. After listening to Jane describe her symptoms of bipolar disorder, I suddenly realized that what she was describing was mercury or heavy metal poisoning. As a biological dentist and one who has experienced first hand the devastating effects of mercury poisoning, I quickly made the connection.
From my own research, mercury as well as other heavy metals (cadmium, aluminum, nickel, etc.) have an affinity for the nervous system as well as being transported via the lymphatic drainage system from the mouth to the rest of the body and particularly to the thyroid gland. Chewing food with teeth that have mercury fillings on the biting surfaces of the bicuspid and molars will cause a release of mercury vapor for a 90 minute period. This fact has been scientifically documented by Drs. Fritz L. Lorscheider and M.J. Vimy of the Department of Medicine and Medical Physiology University of Calgary. It has been estimated that between 3 - 17 micrograms of mercury per day come from undisturbed mercury fillings. This number elevates to as much as 45.49 micrograms/cm2 per day with brushing twice a day. If a person had 12 mercury fillings their exposure would be 29 micrograms per cubic meter of mercury. The Environmental Protection Agency (EPA) says that 30 micrograms per cubic meter per day is the maximum allowable intake from all sources that the average weight person can tolerate before clinical symptoms of mercury poisoning start to show up. When factoring in the EPA's estimate of 10 micrograms of mercury coming from daily intake of food, air and breathing the toxic level of mercury exposure is exceeded! Because mercury is a powerful neurotoxin it plays a major role in causing numerous medical problems and is a major influence in causing cancer. My new book, Reversing Cancer, describes in depth mercury's role in this plague that is now upon us. (156 new cases of cancer are being diagnosed every hour!)
Bipolar disorder causes dramatic mood swing (overly "high" and/or irritable to sad and hopeless), and then back again, often with periods of normal mood in between. Severe changes in energy and behavior go along with these changes in mood. The periods of highs and lows are called episodes of mania and depression. One potential underlying mechanism for which mercury poisoning can replicate the symptoms of bipolar disorder is the migration of mercury to the brain and the thyroid gland. The medical literature describes the mercury poisoning profile with the term "erethism." Erethism consists of subtle or dramatic changes in behavior and pe rsonality, such as depression, irritability, despondency, fearfulness, easily provoked anger, restlessness, indecision, timidity, and a tendency toward easy embarrassment. Companion symptoms are drowsiness, headache, fatigue, dizziness and insomnia with an exaggerated response to stimulation. These represent the neurotoxic symptoms of chronic brain involvement.
Migration of mercury to the thyroid has the potential for causing an under-active or hypothyroid state. Hypothyroidism is associated with severe fatigue and low energy, mental fog, inability to remember, headache, dizziness, poor concentration, low stress tolerance, depression, anxiety, mood swings, insomnia and difficulty in weight control. In addition, numerous other symptoms are associated with a low thyroid: cold hands and feet, dry skin in the winter, infertility, low sex drive, constipation, short windedness, diffuse muscle spasm, excess sleeping, lowered immune system, poor digestion, high cholesterol level that does not respond to medication, heart palpitations and the same symptoms of fibromyalgia.
Below are two lists: signs and symptoms of mania and signs and symptoms of depression.
Signs and symptoms of mania (or a manic episode) include:
- Increased energy, activity, and restlessness
- Excessively "high," overly good, euphoric mood
- Extreme irritability
- Racing thoughts and talking very fast, jumping from one idea to another
- Distractibility, can't concentrate well
- Little sleep needed
- Unrealistic beliefs in one's abilities and powers
- Poor judgment
- Spending sprees
- A lasting period of behavior that is different from usual
- Increased sexual drive
- Abuse of drugs, particularly cocaine, alcohol, and sleeping medications
- Provocative, intrusive, or aggressive behavior
- Denial that anything is wrong
A manic episode is diagnosed if elevated mood occurs with 3 or more of the other symptoms most of the day, nearly every day, for 1 week or longer. If the mood is irritable, 4 additional symptoms must be present.
Signs and symptoms of depression (or a depressive episode) include:
- Lasting sad, anxious, or empty mood
- Feelings of hopelessness or pessimism
- Feelings of guilt, worthlessness, or helplessness
- Loss of interest or pleasure in activities once enjoyed, including sex
- Decreased energy, a feeling of fatigue or of being "slowed down"
- Difficulty concentrating, remembering, making decisions
- Restlessness or irritability
- Sleeping too much, or can't sleep
- Change in appetite and/or unintended weight loss or gain
- Chronic pain or other persistent bodily symptoms that are not caused by physical illness or injury
- Thoughts of death or suicide, or suicide attempts
A depressive episode is diagnosed if 5 or more of these symptoms last most of the day, nearly every day, for a period of 2 weeks or longer.
As a biological dentist, I have clinically witnessed many patients whose blood tests showed normal levels of thyroid hormone but who had many of the symptoms of an under active thyroid. An interesting observation is the fact that with nutritional therapy to chelate out the mercury, many of the above symptoms disappeared. The following letter was unsolicited and sent to me by a patient with whom I nutritionally consulted. This individual was diagnosed with bipolar disorder for 29 years. His father was a dentist and he had a mouth full of mercury fillings. This patient's friend was a dentist who attended one of my seminars and upon returning informed his friend of the above information. After removal and nutritional therapy miraculous results were obtained.
Copper Toxicity and Mental Health
Copper Excess (Toxicity):
Psychological Implications for Children, Adolescents, and Adults
Richard Malter, Ph.D.
Clinical Psychologist
Nutrition Counselor
2295 W. Trail Blazer Drive
Cottonwood , Arizona 86326
(928) 649-9343 Fax: (928) 649-1971
e-mail: rickmind@cableone.net
© April, 1984; June, 2001
Copper Excess (Toxicity): Psychological Implications
for Children, Adolescents, and Adults
INTRODUCTION
There is increasing evidence that significant environmental changes in biochemical factors are contributing to a wide range of psychological problems in children, adolescents, and adults. These problems include: ADD, hyperactivity, distractibility, and memory problems, learning disabilities, depression, anxiety and panic disorder, bipolar disorder, obsessive-compulsive disorder, anorexia, violent aggression, and suicidal tendencies. In fact, there is good reason to believe that there are increasing incident rates of these problems today that are best accounted for by nutritional/biochemical factors. In order to grasp the magnitude of the nutritional/ biochemical problems we are facing today requires a shift in perspective and a new paradigm. The old paradigms and psychological models have become obsolete and are much too limited in perspective.
During the past 20 years, data from hair tissue mineral analyses of children, adolescents, and adults (especially women) point to copper excess (or in extreme cases, copper toxicity) as a major factor associated with many of these psychological problems. The manifestations of these problems are different in preschool and elementary school children, in adolescents, and in adults. One of the major syndromes with which copper excess is associated in younger children is with Attention Deficit Disorder (ADD). Copper excess may be related to ADD with hyperactivity and also without hyperactivity.
The impact of copper excess seems to be much more severe in preadolescent and adolescent girls than in boys. As girls reach puberty, the increase in estrogen levels tends to exacerbate the effects of copper excess because estrogen raises the level of copper in the body’s cells and tissues. When this occurs, there is likely to be an increased risk for behavior and emotional disorders: mood swings, depression and suicidal tendencies, anxiety and panic disorder, irritability and aggression, running away, promiscuity, and eating disorders. Memory, learning, and concentration problems may also increase. Copper excess can be a significant factor contributing to a dramatic increase in the numbers of teen age girls and young women being psychiatrically hospitalized and medicated for “bi-polar” disorder. I consider this diagnosis to be really a “pseudo”-bipolar disorder because the role of excess copper as a contributing underlying factor is rarely if ever identified or considered in the diagnosis and treatment. The eating of foods high in copper content is likely to exacerbate these conditions.
Copper excess also is frequently seen in adults, especially in women. Again, estrogen is a strong contributing factor because of high correlation between copper and estrogen. In addition to the normal increase of estrogen in the menstrual cycle, estrogen also tends to increase in the third trimester of pregnancy, thus contributing to post-partum depression and other psychological problems in some women. Furthermore, women (and adolescent girls) who use the "pill" for contraception increase the amount of estrogen in their system. This is strongly associated with an increased tendency to experience depression, panic disorder, and obsessive-compulsive disorder.
There are a number of environmental factors which further exacerbate the problem of copper excess. For the past forty or forty-five years, the use of copper pipes in household plumbing has contributed substantially to ingestion of increased amounts of copper, especially in the presence of "softened" water. Also, zinc deficient diets may lead to copper excess. Food processing and the deficiency of zinc in our soils are contributing directly or indirectly to the risk of copper excess.
There is some clinical evidence which suggests that copper excess in children with ADD and certain types of behavior disorders may begin in utero. Heavy copper excess in a mother may be strongly associated with copper excess in one or more of her children depending on how much stress she experienced during her pregnancy. The in utero transfer of significant amounts of excess copper to the fetus may also account for the dramatic increase in the number of babies being born with jaundice today. The excess copper is stored primarily in the liver and in the brain. The liver storage can be contributing to the increasing incident rates of jaundice in new-born babies. The brain storage can be contributing to the increasing incident rates of learning and attention deficit disorder.
Clinically, the hair tissue mineral analysis is the best available laboratory test for assessing copper excess or toxicity. However, there are some important technical and dynamic aspects to the identification of copper excess as a possible contributing factor to psychological problems. In some individuals, the first hair tissue mineral analysis may clearly show a high copper level regardless of what is seen in the rest of the mineral profile. In other individuals, what appears to be a near normal level of copper may actually be a very high level in relationship to zinc; that is, the zinc/copper ratio is significantly below normal. These are the two principle ways in which copper excess may manifest itself in the first hair mineral analysis.
In some cases, copper excess may be latent and not be seen so clearly in the first hair mineral analysis. This is because the high amounts of copper may be stored and locked in tissues so that the hair is not picking up the excess amounts. This may be due to the presence of other heavy metals which mask the excess copper. Lead, mercury, cadmium, and/or aluminum may show more readily in the first hair mineral analysis. However, after the individual goes on a nutritional program, the excess copper may be released from tissue storage and will be clearly seen in a subsequent hair mineral analysis.
At the present time, because copper excess is expressed in different ways as a part of a complex dynamic system of interacting nutrient minerals and heavy toxic metals, the review of individual cases is the best method for observing the role of copper excess in a variety of conditions. This is especially true when the copper is masked or hidden in the first hair mineral analysis. The role of latent copper is often missed in most studies using a cross-sectional rather than a longitudinal method of data collection. The nature of the copper excess phenomenon often requires repeated measures over time in order to clearly see the role of copper in many psychological problems.
CASE STUDIES
ADD with Behavioral Hyperactivity
This case illustration is that of a 9 year-old boy referred by his mother. The presenting problems included: "no concentration, can't remember, can't relate to friends, accidents, bumping into things, temper tantrums, chronic depression." Psychological testing indicated that he excelled in verbal concepts and in spatial relations; but, visual-motor and auditory sequential memory problems were evident. On the Davids behavior rating scale, his mother rated him 36/36, which is the most hyperactive rating. White spots were observed on his finger nails. White spots often are associated with a zinc deficiency. Since a low zinc/copper ratio also is indicative of copper excess, white spots are often an indicator of copper excess.
The first hair mineral analysis showed that this boy was a very "fast oxidizer" with a significant sodium/potassium "inversion". This combination -- a fast oxidizer with a sodium/potassium inversion-- is the most common hair mineral analysis profile of hyperactive children. In addition, excessive amounts of lead, cadmium, and aluminum were reported in the first mineral analysis of this boy. However, copper was latent; it was .80 mg/%, a level far below normal (2.5 mg/%).
The second hair mineral analysis was done three months later and showed a major shift in the boy's profile. He had gone into "slow oxidation" with a significant improvement in the hyperactivity ratio of sodium/potassium. Lead, cadmium, and aluminum were still present. However, the copper level had increased from .80 to 24.0! Also, even in the presence of a doubling of the zinc level from 6.0 to 12.0, the zinc/copper ratio dropped from a near normal level of 7.5 (8.0 is the lab's normal zinc/copper ratio) to .50; this is indicative of extreme copper excess. The sharp increase in the hair copper most often indicates the elimination of copper from tissue storage. During this copper "dumping", the hair temporally picks up the increased amount of copper.
During this period of time, the boy's mother reported that she and others who knew the boy observed improvements in his behavioral control, increased calmness, and his ability to anticipate the consequences of his behavior.
Four months later, a third hair mineral analysis showed that his mineral pattern was becoming more balanced and stable with a greatly reduced tendency towards hyperactivity. Excess lead and aluminum had been eliminated along with a very large amount of copper that had dropped from 24.0 to 3.4. The zinc/copper ratio had improved from .50 to 2.95 (still indicative of copper excess, but not quite as severe).
Jim’s mother reported continued behavioral improvements. She also rated his behaviors again on the Davids scale. The new rating score was 25/36 as compared with 36/36, indicating a substantial decrease in hyperactivity. This case clearly illustrates the dynamics of latent copper excess that is only seen over time in two or more hair mineral analyses. It also illustrates how copper can be eliminated in stages from tissue storage.
Adolescent Behavior and Emotional Problems
This case illustrates the role of copper excess in exacerbating behavior and emotional problems in a very bright 13 year-old girl. One year prior to this tissue mineral analysis, the girl began running away from home. She continued to perform well in school, but home problems got worse and worse. She had always been a very difficult child to discipline, but her behavior became more unmanageable for her mother during the past year. The girl was admitted to a general hospital for a neurological and psychological evaluation. All medical tests administered were negative (a hair tissue mineral analysis was not performed.) The psychological evaluation indicated that the girl had a very high IQ, but there were emotional problems and therapy was needed.
The mother believed that there was a problem with the girl's body chemistry which got worse with the onset of puberty. The child had a history of reacting to milk with a runny nose, and she had a tendency to break out in a rash when she ate chocolate. She had dark circles under her eyes and the pediatrician suspected that she had allergies. However, she was never tested for them. The girl complained of being tired, and she tended to sleep a great deal.
After running away again, the girl was admitted to a psychiatric hospital where she stayed for four months. Immediately after being released from this hospital, she ran away again. Her hair mineral analysis showed that, as a slow oxidizer, she had very low energy reserves for coping with stress, Therefore, she tended to avoid stress by running away. The slow oxidation also accounts for her tendency to be chronically tired and to sleep a great deal. The slow oxidation with high copper is associated with depression and suicidal tendencies. She showed suicidal tendencies and was then placed in a state-supported psychiatric hospital. Today, many teen age girls with this high copper mineral pattern are being “diagnosed” with bi-polar disorder. I consider this to be a pseud-bi-polar disorder because the key underlying factor is a copper excess in a slow oxidizer mineral pattern.
Estrogen Replacement Therapy
This case illustrates the relationship between estrogen, copper excess, and slow oxidation. A 49 year-old post-menopausal female was placed on estrogen one and-a-half years prior to the hair analysis described here. She reported being active and energetic prior to the start of the estrogen therapy. She now reports that she feels chronically fatigued and exhausted, has dry skin, has gotten chronic infections, is much more distractible, and has a problem with easily gaining weight. She reports that her mind has been "racing" during the past few months.
The hair mineral analysis chart shows that this woman has a very high copper level (14.8) with a very low zinc level (4.0). The resulting zinc/copper ratio of .27 is indicative of an extreme degree of copper excess. In addition, she is an extremely slow oxidizer with a tissue calcium level of 900! The normal calcium level is 40 mg/%. The high copper results in a lowering of potassium and an increase in tissue calcium. A high calcium/potassium ratio is one of the characteristic ratios of a "slow oxidizer".
The psychological effect of very slow oxidation with a very high copper level is that the person's mind is hyperactive and racing while the person's body feels chronically exhausted and fatigued. The person has all sorts of ideas racing through the mind, but is too tired to act on any one of them. Such an individual easily becomes confused and frustrated. The low energy level of some depressed individuals is associated with very slow oxidation.
THE EXTENT OF COPPER EXCESS
There are a number of factors which suggest that copper excess may have already reached epidemic proportions. Many trends and developments which seem to be unrelated on the surface may have copper excess as an underlying common factor. A recent study reports a doubling of the rate of birth defects in the past 25 years. There appear to be increases in the numbers of children with learning and behavior disorders. The numbers of women with depression, anorexia, and suicidal tendencies seem to be on the increase. Hyperactivity rates among children seem to be increasing. The numbers of exhausted and fatigued young women are increasing. Behavior and emotional problems among adolescent girls are on the increase.
How are the contributing factors coming together to produce the trends which may be strongly related to copper excess? A number of these factors have been mentioned above. These include the extensive use of copper plumbing in homes during the past 25 to 35 years. Depending on the acidity of the water, copper may be leached into drinking and cooking water. Zinc deficient soils produce foods with inadequate zinc supplies to antagonize copper. Stress tends to deplete zinc which allows copper to become more toxic in a person's system. The use of the "pill" on such a massive scale increases the amount of estrogen in a female's system. This results in an increase in tissue copper levels, often resulting in copper excess and "slow oxidation". Pregnant copper toxic women give birth to copper toxic babies who may have birth defects, learning disabilities, and hyperactivity. A copper toxic female child will experience an exacerbation of her copper excess when she enters puberty. Behavior and emotional problems will frequently result. These may involve eating disorders, running away, depression, suicidal tendencies, mood swings, and violent episodes.
Because there is such a strong correlation between estrogen and copper, excess copper in the tissues of a pregnant female may strongly affect her fetus. The problem of copper excess can be passed on from one generation to another. As it is passed on, the problems are likely to become worse. It is suggested here that the problem of copper excess may be characterized by a cumulative effect. That is, as copper excess is passed from one generation to the next, the new generation begins life with a higher load of copper most likely transferred in utero. The quantity increases with continuous exposure to copper-loaded water and other sources of copper in the environment.
Copper excess predisposes one to psychological problems (Pfeiffer, 1975). However, the way in which these problems manifest themselves depends on other factors such as family dynamics, personality structure, physical health, neurological integrity, abilities, developmental history, etc. That is, "copper excess" is a general toxic condition found in many individuals, but the specific psychological and/or physiological problems manifested are unique to each individual. Therefore, the major underlying biochemical "common denominator" of a wide range of psychological and physiological disorders is "copper excess". It is strongly recommended that the most effective treatment for any of these associated disorders must include a treatment for the "copper excess" (general condition) as well as for the specific psychological and/or physiological problem which is manifested in the presenting symptoms and problem (specific condition). The diagnosis and treatment of anorexia nervosa would be a good illustration of this principle. An even more important application of these concepts would be in the direction of preventing anorexia nervosa by the early identification of copper excess in children in the intermediate and junior high grades. By implementing appropriate nutritional programs, the copper excess in individual children can be significantly reduced or eliminated, thereby substantially eliminating a major contributing factor in the development of this disorder. Clinically, we know that the excess tissue copper levels can be significantly reduced with diet, exercise, and proper nutritional supplementation.
Until the extent of the problem of copper excess is recognized and effectively treated, we are likely to see higher incidence rates of related psychological problems. These problems are likely to involve expensive treatments which, at best, will only reduce the symptoms without getting at a major underlying contributing factor. On the positive side, there is nutritional/ biochemical knowledge and, also, the laboratory technology available which permit us to identify the copper excess condition and to effectively reduce its psychological and physical impact. A nutritional program will enable us to build a more solid underlying biochemicalfoundation on which to build other treatment and intervention programs. The resulting synergistic effect would very likely speed up treatment of many psychological problems related to copper excess and drastically reduce diagnostic and treatment cost. Treatments would also be much more effective and longer lasting in psychological improvement.
References
Adams, P. et. al. "Effect of vitamin B-6 upon depression associated with oral contraception." The Lancet, April 28, 1973, pp. 897-904.
Brenner, A. "The effects of megadoses of selected B-complex vitamins on children with hyperkinesis: controlled studies with long-term follow-up." J. of Learning Disabilities, May, 1982, 15, pp. 258-264.
Malter, R. "Implications of a bio-nutritional approach to the diagnosis, treatment, and cost of learning disabilities." Paper presented at the Association for Children with Learning Disabilities International Conference, Washington, D.C., 1983.
Malter, R. "Trace mineral profiles of hyperactive children." Unpublished research paper. Northwest Suburban Child Development Clinic, Inc., Arlington Heights, Illinois, 1984.
Pfeiffer, C. Mental and Elemental Nutrients: A Physician's Guide to Nutrition and Health Care. New Canaan: Keats, 1975.
Rimland, B. & Larson, G. "Hair mineral analysis and behavior: an analysis of 51 studies." J. of Learning Disabilities, May, 1983, 16, 279-285.
Walsh, W. Study of hair mineral analysis related to violent behavior as reported in Science News, August 20, 1983.
Barkoff, J.R. "Urticaria secondary to a copper intrauterine device." International J. of Dermatology, 1976, 15, pp. 594-95.
Crook, W.G. et. al. "Systematic manifestations due to allergy: Report of 50 patients and a review of the literature on the subject (sometimes referred to as allergic toxemia and the allergic tension-fatigue syndrome)", 1961, Pediat., 27, pp. 790-799.
Crook, W.G. The Yeast Connection. Jackson, Tenn: Professional Books,1984.
Shelley, W.B. et. al. "Cholinergic Urticaria: Acetylcholine-receptor-dependent immediate hypersensitivity reaction to copper." The Lancet, April 16, 1983, pp. 843-846.
Thursday, May 14, 2009
Chinese Medicine Theory and treatment
Sunday, May 10, 2009
what causes mental illness?
Ask any psychiatrist or doctor what causes mental illness and they will tell you the same thing – no one knows exactly. There does appear to be a strong genetic factor in illnesses such as bipolar disorder, clinical depression and schizophrenia. Even though the gene location was recently discovered, the way the illnesses happen is still a mystery. Yet some intriguing possibilities are now coming to light.
chemical imbalances in the brain
The most common explanation for mental disorders is a chemical imbalance in the brain, but how and why these imbalances happen is not yet known. Since a complex web of nutrients, such as zinc, vitamin B6 and B12, are the building blocks that the brain needs to make the right amounts of important chemicals such as neurotransmitters, it makes sense that a lack of these nutrients could cause the chemical imbalances of mental illness.
a genetic need for more nutrients
As early as the 1960s, Dr. Linus Pauling, winner of two Nobel Prizes, speculated that some people have a genetically-based need for more vitamins and minerals than other people. He wondered if mental illness could be the result of failing to meet these extra requirements. Research is now showing that Dr. Pauling may have been right. Dr. Bruce Ames, at the University of California, Berkley, has shown that genetic mutations often result in an increased need for nutrients. He also found that taking extra amounts of these nutrients could correct the deficiencies. If a person with a genetic need for more nutrients does not get them or cannot absorb them, it makes sense that this person would, over time, become deficient.
lack of nutrients affect brain growth factors
Brain growth factors are necessary for keeping the neuron branches healthy and connected, so that proper signals can be sent. Many nutrients have been shown to increase brain growth factor levels. And a lack of these same nutrients leads to brain cell shrinkage and brain cell death. It's not a stretch to imagine that this could play a significant role in mental illnesses.
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